bone metastasis_gurmit singh,shafaat.a.rabbani
Bone Metastasis: Experimental and Clinical Therapeutics is intended as an introduc-
tion to the molecular underpinnings of bone metastasis. Contributions from internation-
ally recognized authorities on the fundamental concepts, current treatment approaches,
and future therapeutic strategies provide a synopsis of bone metastasis. Our insights into
the molecular mechanisms underlying the pathophysiology of bone metastasis are still
evolving. These advances are driving the application of new therapeutic strategies di-
rected at recently discovered molecular targets.
The first 11 chapters in Bone Metastasis: Experimental and Clinical Therapeutics
focus on fundamental concepts associated with the process of metastasis. The roles of the
various autocrine, paracrine, and immunological factors are intimately involved in the
progression and establishment of bone metastases. Understanding these concepts has led
to and will continue to provide novel approaches to their treatment. Chapters 12–19
discuss various strategies that appear to have promise and that are currently deployed in
treatment or are at the experimental stage. Understanding of the physiological process
that leads to bone degradation, pain, angiogenesis, and dysregulation of bone turnover by
the tumor is critical. Thus, the treatment of bone metastases may need to be individual-
ized, employing a combination of surgical, radiation, and/or pharmacological maneu-
vers. Further understanding of various pharmacogenomic parameters and tissue
environmental factors is essential for progress beyond the current standard approaches
of using radiation and/or bisphosphonates for palliation.
this book in Amazon.com
